That was to say, for achieving the plateau period (80% of Emax) of SGLT-2 inhibitors on UACR in T2DM patients, 10 mg/day dapagliflozin (or 100 mg/day canagliflozin) should be taken for at least 1.792 weeks, which could provide reference for clinical medication care. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.