DUX4 and facioscapulohumeral muscular dystrophy: In FSHD cells, the recruitment of dCas9-KRAB to the DUX4 promoter or exon 1 results in increased levels of KAP1, HP1α and HP1β and moderately decreased levels of activating H3K27ac mark and RNA Pol II recruitment (Himeda et al., 2016).