In FSHD cells, the recruitment of dCas9-KRAB to the DUX4 promoter or exon 1 results in increased levels of KAP1, HP1α and HP1β and moderately decreased levels of activating H3K27ac mark and RNA Pol II recruitment (Himeda et al., 2016). The gene discussed is DUX4; the disease is Facioscapulohumeral dystrophy.