The major role of the DUX4 PAS in the FSHD has been demonstrated in multiple articles (Bakker et al., 1995; Lemmers et al., 2010; Lemmers et al., 2022) and strategies aiming at destabilizing the DUX4 mRNA by targeting its PAS using antisense oligonucleotides or U7snRNA have been successfully developed in vitro and in vivo (Chen et al., 2016; Marsollier et al., 2016; Ansseau et al., 2017; Lu-Nguyen et al., 2021; Rashnonejad et al., 2021; Lu-Nguyen et al., 2022). Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.