After adjusting for age, NIHSS score, history of atrial fibrillation, mechanical thrombectomy status, blood CRP levels, stroke classification, and syndecan-1 levels, logistic regression analysis (Model 2) revealed that syndecan-1 levels remained significantly associated with unfavorable prognosis in patients with AIS treated with intravenous thrombolysis (p < 0.001, Table 2). This evidence concerns the gene SDC1 and Stroke.