Since previous studies had shown a protective role of Adora2b signaling during DSS colitis (Eltzschig et al., 2009b; Frick et al., 2009; Aherne et al., 2015; Aherne et al., 2018) or intestinal ischemia and reperfusion (Hart et al., 2009), subsequent studies addressed the functional role of the Adora2b in netrin-1-elicited gut protection. Here, NTN1 is linked to colitis.