Indeed, measurements of alveolar fluid clearance directly implicate Adora2b signaling in the enhancement of amiloride-sensitive fluid transport and elevations of pulmonary cAMP during ARDS induced by mechanical ventilation, suggesting that Adora2b agonist treatment (such as BAY 60-6583 or netrin-1) could provide protection during ARDS by “drying out” the lungs (Eckle et al., 2008c; Eckle et al., 2013b; Hoegl et al., 2015; Wang et al., 2021b). This evidence concerns the gene ADORA2B and acute respiratory distress syndrome.