HIF1A and acute respiratory distress syndrome: Importantly, several previous studies demonstrate that HIF1A is stabilized during ARDS, and can function to dampen alveolar inflammation (Eckle et al., 2013a; Eckle et al., 2014; Vohwinkel et al., 2015; Garcia-Morales et al., 2016a; Vohwinkel et al., 2021).