NTN1 and myocardial ischemia: Several previous studies have implicated netrin-1 signaling in attenuating myocardial ischemia and reperfusion injury (Mao et al., 2014), and have also identified signaling events related to classic netrin-1 receptors, e.g., via DCC signaling (Zhang and Cai, 2010; Bouhidel et al., 2015; Li et al., 2015).