This is likely mediated by stimulation of the innate immune system and is consistent with our previous findings that pre-stimulation of the innate immune system by a single low-dose LPS or M-CSF injection 1 day before stress exposure prevents the onset of behavioral abnormalities in CSDS mice (Gu et al., 2021; Ji et al., 2021) and showed that amphotericin B liposomes could be developed as a novel drug to prevent the onset of mental disorders. The gene discussed is CSF1; the disease is psychiatric disorder.