According to Liu et al., after transient middle cerebral artery occlusion, Epac2−/− mice showed a more severe neuronal injury than Epac1−/− mice, indicating that Epac2, rather than Epac1, plays an important role in cerebral function rescue following an ischemic stroke (Liu et al., 2015). The gene discussed is RAPGEF4; the disease is ischemic stroke.