HDAC6 and liver dysplastic nodule: In the current study, by interrogating the CMap profile with tubulointerstitial transcriptomic data from renal biopsy-proven early- and late-stage DN patients, we found that CAY10603, a specific inhibitor of HDAC6 (Sixto-López et al., 2019), significantly reversed the transcriptomic signatures in the tubulointerstitial component of DN.