The NLRP3 inflammasome not only amplifies renal inflammation but also promotes renal fibrosis, so NLRP3 inflammasome activation contributes significantly to the pathogenesis and progression of DN (Shahzad et al., 2016; Chi et al., 2017; Andrade-Oliveira et al., 2019; Wu et al., 2021). The gene discussed is NLRP3; the disease is renal fibrosis.