Specifically, ASS1 overexpression effectively inhibits tumor growth by activating PERK/eIF2α/ATF4/CHOP axis in Huh7 and SNU475 cells, indicating upregulating tumoral ASS1 expression as a promising strategy in tumors with low ASS1 expression (Kim et al., 2021). This evidence concerns the gene EIF2AK3 and neoplasm.