Mechanisms of ACSL4 involvement in tumor development may include iron-dependent, non-apoptotic, and cell death pathways (Doll et al., 2017), drug resistance caused by metabolic recombination (Orlando et al., 2019), arachidonic acid-dependent tumorigenesis (Orlando et al., 2012), steroid production (Wang et al., 2019) and activation of intracellular pro-cancer signaling pathways (Wu et al., 2015). The gene discussed is ACSL4; the disease is cancer.