ACSL4 and colorectal cancer: ACSL/stearoyl-CoA desaturase (ACSL1/ACSL4/SCD) metabolic network disorders, resulting in elevation of acylcarnitines, downregulation of polyunsaturated fatty acids (PUFA), and upregulation of monounsaturated fatty acids (MUFA), could cause invasion and poor prognosis in colorectal cancer (Sánchez-Martínez et al., 2017).