Commonly, in ACSL4 high expressing cancers (e.g., colon or ovarian cancer), increased expression of ACSL4 typically predicts unfavorable outcome/prognosis, while in the ACSL4 low expressing cancers (e.g., liver cancer), decreased expression of ACSL4 is corelated to unfavorable outcome/prognosis. Here, ACSL4 is linked to liver cancer.