Several studies (Bortolozzo et al., 2018; Righetti et al., 2014) using ovalbumin (OVA)-induced models of asthma have shown functional and structural alterations in the respiratory system associated with the high expression of TGF-β, MMP-9, MMP-12 positive cells, and Th2 cytokines: the increased deposition of actin and elastic fibers, and increased mucus production among big and small airways. The gene discussed is TGFB1; the disease is asthma.