ESR1 and triple-negative breast carcinoma: The compounds were tested for growth inhibition, apoptosis induction, and cell cycle arrest in human breast cancer cell lines such as MDA-MB-231 (triple-negative breast cancer cells) and MCF-7 (estrogen receptor-positive breast cancer cells), primary breast cancer cells (in-house cultured), BCSC, and parental BCSC (BCSC-P).