The serum, glucose, total cholesterol, LDL and HDL triglyceride contents were lower in the groups treated with capsanthin-enriched pellets and capsaicin pellets than in the control group fed high-fat diet (HFD), whereas the obesity marker adiponectin was significantly higher in the groups fed capsanthin-enriched pellets and capsaicin pellets. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.