Neuronal cell bodies in the trigeminal (TG) and upper cervical ganglia (C2/3DRG) and axonal fibers of this innervation express CGRP and its receptors (8, 9), for which current therapies blocking their pathways are proving effective at significantly reducing migraine and allodynia in nearly half of patients (10, 11). The gene discussed is CALCA; the disease is migraine disorder.