With this approach, it will be possible to manipulate disease-associated microglial genes in iPSC-MG, such as mutated C-X3-C motif chemokine receptor 1 (CX3CR1) in schizophrenia and autism spectrum disorder (Ishizuka et al., 2017) and mutated CSF1R in hereditary diffuse leukoencephalopathy with spheroid (HDLS) (Nicholson et al., 2013). This evidence concerns the gene CX3CR1 and Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia.