With this approach, it will be possible to manipulate disease-associated microglial genes in iPSC-MG, such as mutated C-X3-C motif chemokine receptor 1 (CX3CR1) in schizophrenia and autism spectrum disorder (Ishizuka et al., 2017) and mutated CSF1R in hereditary diffuse leukoencephalopathy with spheroid (HDLS) (Nicholson et al., 2013). Here, CX3CR1 is linked to schizophrenia.