SOX2 and Dravet syndrome: With the discovery of the “Yamanaka factors,” Oct3/4, Sox2, c-Myc, and Klf4, that are sufficient to reprogram terminally differentiated cells back to a pluripotent state (Takahashi and Yamanaka, 2006), iPSCs derived from individuals with DS have been produced to study cellular and molecular underpinnings of DS while circumnavigating the drawbacks of mouse models.