With the discovery of the “Yamanaka factors,” Oct3/4, Sox2, c-Myc, and Klf4, that are sufficient to reprogram terminally differentiated cells back to a pluripotent state (Takahashi and Yamanaka, 2006), iPSCs derived from individuals with DS have been produced to study cellular and molecular underpinnings of DS while circumnavigating the drawbacks of mouse models. This evidence concerns the gene KLF4 and Dravet syndrome.