The effects of medications, i.e., antidiabetics, antihypertensives, beta-blockers, calcium channel blockers, and agents acting on the renin-angiotensin system (that mirror cardiovascular and metabolic diseases too) on serum biomarker levels were non-significant in all analyses (data not shown) with the exception of significant effects of antidiabetic drugs on serum NSE levels (beta = −0.02, p = 0.04). The gene discussed is ENO2; the disease is metabolic disease.