AQP4 and glioma: In particular, numerous studies addressed the possible role of AQP4 in glioma-related edema, as well as in the regulation of glioma cell proliferation, invasivity, cell migration, and the brain glymphatic system (Yang et al., 2011; Lan et al., 2017; Hubbard et al., 2018; Simone et al., 2019; Toh and Siow, 2021).