AQP4 and central nervous system cancer: Interestingly, TAMs express VEGF, IL-1, MMPs, or AQP4, which are all implicated in the pathogenesis of glioma-related edema (Saadoun et al., 2002a; Carlson et al., 2007; Gabrusiewicz et al., 2011; Herting et al., 2019).