HIF1A and neoplasm: VEGF overexpression has been shown to be driven by specific genetic mutations, by HIF-1α under hypoxic conditions, or through autocrine secretion in the tumor microenvironment (Lin et al., 2004; Steiner et al., 2004; Wang et al., 2014; Wen et al., 2017; Almiron Bonnin et al., 2018).