According to the results of the Lasso-selected features, Calponin 1 (CNN1), Myosin Heavy Chain 11 (MYH11), RNA Binding Motif Single Stranded Interacting Protein 1 (RBMS1), and Methionine Sulfoxide Reductase B3 (MSRB3) were identified and added to the multigene signature that predicts the survival of GC patients. The gene discussed is MSRB3; the disease is gastric cancer.