Recently, studies have revealed that circ-ITCH is down-regulated in multiple tumor tissues, and regulates cell proliferation, migration, invasion and apoptosis of malignant tumor, indicating it might be an important tumor suppressor (Li Y. et al., 2020; Ghafouri-Fard et al., 2021; Su et al., 2022). The gene discussed is ITCH; the disease is neoplasm.