Circ-ITCH specifically targets miR-106b-5p and miR-421 in clear cell renal cell carcinoma (ccRCC) and oral squamous cell carcinoma (OSCC) to up-regulate PDCD4 expression and prevent tumor progression, respectively (Hao et al., 2020; Gao et al., 2021). The gene discussed is PDCD4; the disease is neoplasm.