The expression of circ-ITCH is linked to the prognosis of a range of tumors, including HCC, EOC, PCa, BCa, OC, and so on, according to Kaplan-Meier survival analysis (Guo et al., 2017; Luo et al., 2018a; Yang et al., 2018; Wang S. et al., 2019; Wang X. et al., 2019; Huang et al., 2019; Lin et al., 2020). Here, ITCH is linked to hepatocellular carcinoma.