SYK and cancer: In this study, we also found SYK was heterogeneously expressed in different normal tissues and cancer cells (p < 0.05, Supplementary Figures S1A, B), and was significantly differently up-expressed and down-expressed in the multiple tumors (p < 0.05, Supplementary Figures S1C, D), which was consistent with SYK’s dual role as a tumor promoter and tumor suppressor.