A large cohort GWES study by Sheng C. J. et al. in 2017 showed a totally different recurrently gene pattern that variants in gene GDF1 account for ∼5% of severe CHD in Ashkenazim, variants in gene MYH6 accounting for ∼11% of Shone complex, and variants in gene FLT4 accounting for 2.3% of Tetralogy of Fallot (TOF) (Jin et al., 2017). Here, FLT4 is linked to coronary artery disorder.