By in-depth interpretation, we identified and proposed eight candidate CHD association genes: SYNE2, MYLK, PKP2, TRPM4, MIB1, TCAP, SON, and DSP. They all have defined molecular pathogenic mechanisms associated with the abnormal cardiac phenotype and detected protein-truncating variants that are considered pathogenic or likely pathogenic variants according to ACMG rules. This evidence concerns the gene PKP2 and coronary artery disorder.