Among the enriched 12 KEGG pathways, in concordance with the 886 gene set, the ECM-receptor interaction has the most significant FDR (1.80E-10) and three pathways have the equally second most significant FDR (5.14E-05), which include the PI3K-Akt signaling pathway, focal adhesion and dilated cardiomyopathy (Supplementary Table S9). This evidence concerns the gene AKT1 and dilated cardiomyopathy.