NIPBL and coronary artery disorder: Except for gene KDR, there are recurrence variants in genes MED13L and ANK3. Gene SMAD6, NIPBL, ATP2C1, and APC all have a recurrence in two CHD samples [1.65%, 95%CI (0.08%–6.20%)], and the other three genes, with the exception of SMAD6, all have recurrence variants.