To conclude, the results of the present study elucidate that rs578595 at WDR72 is significantly associated with calcium nephrolithiasis, whereas rs1037271 at DGKH, rs12626330 at CLDN14, rs12654812 at SLC34A1 and rs12539707 at HIBADH show suggestive associations with nephrolithiasis in Chinese Han population. This evidence concerns the gene CLDN14 and Calcium nephrolithiasis.