Moreover, it is noteworthy that mice lacking Fbn2 display a limb-patterning defect (syndactyly), due to the impaired balance between chondrogenic outgrowth and interdigital cell death, which are under the control of several signaling molecules, including BMPs (Arteaga-Solis et al., 2001). The gene discussed is FBN2; the disease is syndactyly.