MET and gastric cancer: MET activation triggers a downstream cascade of phosphoinositide 3-kinases (PI3K) and Rat sarcoma virus (RAS) signaling and regulates cell survival and proliferation (Zhang et al., 2018), Thus, the over-activation of MET plays a critical role in cancer development and is frequently identified in various types of tumors, including GC (Ariyawutyakorn et al., 2016).