COL10A1, which encodes Collagen type X alpha 1, was found to be overexpressed in different types of cancer, such as esophageal cancer and breast cancer, and promoted the malignant progression by upregulating the expression of Prolyl 4-hydroxylase beta polypeptide (P4HB) (Song et al., 2021; Yang et al., 2021). The gene discussed is P4HB; the disease is esophageal cancer.