SPARC and gastric cancer: Another study demonstrated that COL1A1, Collagen Type V Alpha 2 Chain (COL5A2), Prolyl 4-Hydroxylase Subunit Alpha 3 (P4HA3), and Secreted Protein Acidic And Cysteine Rich (SPARC) showed vital values in prognosis and diagnosis of GC (Niu et al., 2022).