For example, a bioinformatics analysis by Liu et al. (Liu et al., 2018b) found nine hub genes, including DNA Topoisomerase II Alpha (TOP2A), collagen type I alpha 1 chain (COL1A1), COL1A2, NDC80 Kinetochore Complex Component (NDC80), Collagen Type III Alpha 1 Chain (COL3A1), Cyclin Dependent Kinase Inhibitor 3 (CDKN3), Centrosomal Protein 55 (CEP55), Targeting protein for Xklp2 (TPX2), and TIMP Metallopeptidase Inhibitor 1 (TIMP1), that might be associated with the pathogenesis of GC. The gene discussed is TIMP1; the disease is gastric cancer.