Moreover, through lasso regression analysis, we further removed 5 genes that were redundant and thus 10 genes were used as prognostic genes, namely, CACNA1C, COL4A5, ADRA2B, EGFR, LMBR1L, FZD7, PKM, IL20RB, PMCH, and EPHB2. A previous study represent that EGFR is over expressed in activated CAFs, contributing to colon cancer development (Shin et al., 2019). Here, ADRA2B is linked to malignant colon neoplasm.