To address this question, we analyzed the correlation between CAMK1D, CENPV, and TRHDE and immune cells, and finally found that CENPV expression had a direct negative correlation with resting memory CD4 T cells, and TRHDE expression had a strong positive correlation with naive B cells; we venture to guess that CENPV and TRHDE may regulate resting memory CD4 T cells and naive B cells through certain pathways, and have an impact on disease progression remission or recovery in NAFLD in terms of immune and inflammatory responses. The gene discussed is CAMK1D; the disease is metabolic dysfunction-associated steatotic liver disease.