In a study of the genetic basis of thyrotropin receptor antibodies and hyperthyroidism in mice immunized with CXB recombinant inbred strains, it was uncovered that the TRHDE expression is controlled by thyroid hormones and is linked to genes related to thyroid function, which represents an extremely intriguing result (Aliesky et al., 2006). This evidence concerns the gene TSHR and hyperthyroidism.