To address this question, we analyzed the correlation between CAMK1D, CENPV, and TRHDE and immune cells, and finally found that CENPV expression had a direct negative correlation with resting memory CD4 T cells, and TRHDE expression had a strong positive correlation with naive B cells; we venture to guess that CENPV and TRHDE may regulate resting memory CD4 T cells and naive B cells through certain pathways, and have an impact on disease progression remission or recovery in NAFLD in terms of immune and inflammatory responses. This evidence concerns the gene CD4 and metabolic dysfunction-associated steatotic liver disease.