In detail, TMEM154, TSPAN3, CAMK1D, TRHDE, PEG10, ME1, SATB2, SNAP25, ANKRD18A, ISM1, and SGCB were upregulated in NAFLD, while APOF, SYP, OPN3, CENPV, IGF1, AMDHD1, P4HA1, and MRPL21 were downregulated within NAFLD samples (Figure 1D). The gene discussed is ISM1; the disease is metabolic dysfunction-associated steatotic liver disease.