Transcription through genes containing repeat expansions in Huntington's Disease (the HTT gene) (16–18), Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) (C9orf72) (20,21,56), and Spinocerebellar Ataxia type 36 (SCA36) (NOP56) (22) has been reported to be affected differentially by knockdown of Supt4h or Supt5h. This evidence concerns the gene HTT and frontotemporal dementia.