In our study, cellular senescence of HCC cells was triggered by AGTR1 knockdown in accordance with weakened proliferative ability, G2-M phase arrest, and increased expression of p53 and p21 as well as the proportions of SA-β-Gal- and SAHF-positive cells, indicating that AGTR1 attenuated tumor cellular senescence during HCC progression. The gene discussed is TP53; the disease is neoplasm.