Nowadays, single or combination treatments of encorafenib have been explored in various BRAF mutant cancers, such as SKCM, PAAD, LUAD, COADREAD, THCA, and other advanced solid tumors in a clinical trial (NCT05003622; NCT04390243; NCT05195632; NCT04673955; NCT04061980; NCT03973918). The gene discussed is BRAF; the disease is cancer.