In a recent study by Noreen et al. (2019), the silencing of Tet methylcytosine dioxygenase 1 (TET1) oxidative DNA demethylase mediated by BRAF V600E mutation was responsible for the initiation of colon cancers with CpG-island methylator phenotype (CIMP). Here, BRAF is linked to malignant colon neoplasm.