To date, the variant of concern (VOC) is Omicron variant (B.1.1.529), which harbors as many as 36 substitutions in viral S protein and total 59 mutations in whole genome compared with SARS-CoV-2 ancestral strain, leading to immune evasion from neutralization by vaccination- and infection-induced antibodies (Woldemeskel et al., 2022). The gene discussed is PROS1; the disease is infection.