CD8A and melanoma: Consistent with these observations, bulk RNA-seq gene expression data (TCGA cohort) analyses of human melanoma samples across primary lesions, metastatic skin, and visceral metastases, confirmed TIL-B (CD79A) gene expression to positively correlate with tumor-infiltrating T lymphocyte (TIL-T) (CD3), and cytotoxic T lymphocyte (CD8A+) gene expression, in both primary melanomas, as well as skin and visceral metastases (Spearman’s rank correlation test to calculate correlation coefficients (r) and p-values) (Figure 3(e)).