10 A novel IgG4+ CD49b+ CD73+ B cell subset has been reported in the peripheral blood and tumors of melanoma patients, which expressed pro-angiogenic and inflammatory mediators including VEGF, CYR61, ADM, FGF2, PDGFA, and MDK, and promoted endothelial cell tube formation in vitro. The gene discussed is VEGFA; the disease is melanoma.