PKM and cancer: Intriguingly, HITT expression was dramatically reduced upon glucose starvation, which was accompanied by reduced HITT and PKM2 interaction (Figure 5(a)); siRNA-mediated PKM2 inhibition induced glucose starvation-induced cell death (Figures 5(b)–5(e)), while PKM2 overexpression improved the adaptive survival of cancer cells under glucose starvation (Figures 5(f) and 5(g)).