THEM6 and bladder transitional cell carcinoma: Furthermore, chemokines which can induce antigen-presenting cell and TIIC recruitment were downregulated in the THEM6-high expression group in BLCA TME, including CXCL9, CXCL10, CXCL13, CCL2, CCL3, CCL4, CCL11, CCL13, CCL18, CCL19, CCL21, CCL23, and CCL26. Paired receptors with these chemokines like CCR1, CCR2, CCR4, CCR5, CCR6, CCR8, CXCR4, CXCR5, and CXCR6 were also negatively correlated with THEM6 mRNA expression (Figure 2(a)).