On the contrary, one of the TRPV1 agonists, capsaicin, can partially reverse the effect of CCl4 on the aforementioned indicators, further implying that capsaicin may activate TRPV1, which may affect the function of CCl4 in hepatic fibrosis and TGF-β in HSC activation. This evidence concerns the gene TGFB1 and Hepatic fibrosis.