In this study, the functional significance of TRPV1 in HSC activation and hepatic fibrosis progression was evaluated based on histopathology, serology, cellular, and molecular characteristics using microdissected specimens obtained from either patients with a similar stage of cirrhosis or classic carbon tetrachloride- (CCl4-) induced murine fibrosis model, namely, CCl4-induced WT and KO mice underwent various experimental procedures. The gene discussed is TRPV1; the disease is fibrosis.