RBFOX1 is an RNA-binding protein that regulates splicing of epilepsy candidate genes (e.g., GABRG2, SYN1, KCNQ2, SCN8A, SLC12A5) and plays a key role in neuronal excitation and may cerebral cortex development (17), changes to transcriptomic expression and splicing patterns of neuronal genes (18), and miRNA crosstalk that impacts homeostatic downscaling of excitatory synapses (19). This evidence concerns the gene RBFOX1 and epilepsy.