Recently, histone H3K9 β-hydroxybutyrylation (H3K9bhb) upregulates matrix metalloproteinase-2 (MMP-2) to antagonize glomerulosclerosis in diabetic rat [25]; H3K9bhb ameliorates aortic endothelial injury by promoting the generation of vascular endothelial growth factor (VEGF) in diabetic rats [26]. This evidence concerns the gene VEGFA and glomerulosclerosis.