The invasion and migration ability and MMP-2 and MMP-9 protein expression levels of HuH-7 hepatoma cells in the PI3K activator group significantly increased (P < 0.05), while the invasion and migration ability of MMP-2 and MMP-9 protein expression levels of HuH-7 hepatoma cells in the circFOXO3 mimic group significantly increased. The gene discussed is MMP2; the disease is hepatocellular carcinoma.