CASP3 and hepatocellular carcinoma: Compared with the circFOXO3 mimic group, the vitality and Bcl-2 protein expression level of HuH-7 hepatoma cells in the circFOXO3 mimic + PI3K activator group significantly increased (P < 0.05), while the apoptosis rate, Caspase-3, and Bax protein expression level of hepatoma cells significantly decreased (P < 0.05), as given in Table 3.