Meta-analysis results showed that in older SCH patients, levothyroxine can significantly reduce cholesterol (TC) (<i>p</i> < 0.00001), triglyceride (TG) (<i>p</i> < 0.00001), low-density lipoprotein cholesterol (LDL-C) (<i>p</i> = 0.03) and apolipoprotein B (ApoB) (<i>p</i> < 0.00001). This evidence concerns the gene APOB and spindle cell hemangioma.