Widely expressed by a variety of tissues—including osteoblasts, cardiomyocytes, hepatocytes, neuronal cells, colon, lungs, and myocytes — WISP1 was recently validated as a novel adipokine released from human adipocytes and linked to inflammation and insulin resistance in obesity (69, 70). Here, CCN4 is linked to obesity due to melanocortin 4 receptor deficiency.