Similarly, among the 15 anti-inflammatory organokines, 7 (adiponectin, Omentin-1, ZAG, SFRP5, CTRP3, IL-10, and DEL-1) showed reduced levels and 8 (LCN2, VASPIN, IL-1RA, FGF21, GDF15, MANF, Irisin, and IL-6) showed elevated levels in patients with obesity. This evidence concerns the gene SFRP5 and obesity due to melanocortin 4 receptor deficiency.