IGF1 and SHOX-related short stature: It has to be noted that not only GHD but also ISS is regarded as a disorder of the GH-IGF-1 axis, falling between GH deficiency and GH insensitivity in the so-called GH-IGF-1 axis continuum model (25), but differing from GHD for the response to GH stimulation test (20, 25).