The link between SIRT1-mediated autophagy and T2DM is described in a recent study by Ren et al., demonstrating that metformin treatment attenuated fat diet induced-T2DM condition in a rat model with elevated levels of SIRT1, Beclin1, ATG12, LC3, and FOXO1. The gene discussed is MAP1LC3A; the disease is type 2 diabetes mellitus.