The link between SIRT1-autophagy-T2DM axis is further supported by a study performed by Ma et al. According to the study, SIRT1 knockout rats not only showed less amelioration of the T2DM condition with resveratrol treatment but also showed a decrease in the autophagy markers (ATG5, ATG7, and LC3) (79). The gene discussed is ATG5; the disease is type 2 diabetes mellitus.