SLE-hypothyroidism patients had a lower rate of the use of glucocorticoids/immunosuppressants treatment within three months before hospitalization, higher level of ESR, creatinine, 24h urine protein, triglyceride and diastolic blood, lower level of C3, albumin and HDL, and a higher rate of low C4 than SLE-euthyroidism patients (Table 2). This evidence concerns the gene ALB and hypothyroidism.