Beyond all expectations, our findings declared a novel underlying molecular mechanism of SNHG6/miR-944, LINC00520/miR-577, PCAT6/miR-326 DANCR/miR-577, and KCNMB2-AS1/miR-374a-3p signaling axis in promoting DN progression, which indicates that these genes may serve as a therapeutic target of DN. This evidence concerns the gene PCAT6 and liver dysplastic nodule.