As regard to biochemical parameters, there was no difference in FPG and HbA1c between the two groups and diabetic men with CAD had higher levels of AST, FFA, Urea, Cr, hsCRP and FGF21 (p all <0.001), while HDL-C, eGFR and testosterone levels were lower (p all <0.01), unmasking existence of inflammation, unfavorable lipid metabolism, and relatively poor renal function in diabetic men with CAD. The gene discussed is FGF21; the disease is coronary artery disorder.