After combining the data derived from all the stromal slices (LM-NEN and HCC), we observed that the release of sCD40 and sPD-1 was significantly higher in the LM-NEN epithelial tumour slices (p=0.0286) and a similar trend was detected for sCD137, sCD80, IDO-1, sLAG3, sBTLA, sGITR and sPD-L2 (p=0.0571). Here, LAG3 is linked to hepatocellular carcinoma.