To detect the expression of inflammatory factors such as interleukin-1β (IL-1β), interleukin-6 (IL-6), transforming growth factor (TGF-β), and tumor necrosis factor (TNF-α) in the tumor tissue of ventricular septal defect (VSD) in congenital heart disease and to explore the role of inflammatory response in the formation of aneurysmal perimembranous VSD(APVSD). The gene discussed is TNF; the disease is neoplasm.