The expression levels of IL-1β, IL-6, TGF-β, and TNF-α in the perimembranous tissue of aneurysm in both groups were negatively correlated with the width of the APVSD breach IL-1β, IL-6, TGF-β, and TNF-α may be involved in the occurrence and development of APVSD through inflammatory mechanisms. The gene discussed is IL1B; the disease is aneurysm.