By performing RT-PCR and Western blot, we confirmed that HS3ST1 overexpression or knockdown significantly decreased or increased SPOP expression in NSCLC cells, respectively (Figures 7(a)–7(c)), Moreover, the level of SPOP was substantially lower in NSCLC samples compared to that in the adjoining normal samples (Figure 7(d)). The gene discussed is SPOP; the disease is non-small cell lung carcinoma.