HS3ST1 and non-small cell lung carcinoma: By performing RT-PCR and Western blot, we confirmed that HS3ST1 overexpression or knockdown significantly decreased or increased SPOP expression in NSCLC cells, respectively (Figures 7(a)–7(c)), Moreover, the level of SPOP was substantially lower in NSCLC samples compared to that in the adjoining normal samples (Figure 7(d)).