Importantly, overexpression of VGF in preclinical 5xFAD mouse AD models, via germline overexpression, AAV-mediated VGF delivery, or long-term icv TLQP-62 or TLQP-21 peptide administration, reduced amyloid load, phospho-tau levels, synaptic pathology, dystrophic neurite damage, astrogliosis, microgliosis, and memory impairment, and rescued neurogenesis and LTD deficits (Beckmann et al., 2020; El Gaamouch et al., 2020). Here, VGF is linked to memory impairment.