This finding is in agreement with Telles S et al who reported a negative association between FPG and HDL cholesterol levels, but a positive correlation between FPG and waist circumference in healthy obese adults.20 Elevated hepatic insulin resistance is a typical finding in isolated IFG, with almost normal skeletal muscle sensitivity.21 Drew et al showed that high-density lipoprotein could modulate glucose metabolism by promoting insulin secretion and by activating AMP-activated protein kinase in skeletal muscles. The gene discussed is INS; the disease is Insulin resistance.