Alzheimer's disease (AD), the major cause of dementia in the elderly, is pathologically characterized by three components: (i) extracellular deposits of amyloid‐β peptide (Aβ), (ii) intracellular neurofibrillary tangles (NFT) that is composed of hyper‐phosphorylated tau protein (p‐tau), and (iii) microglia‐dominated inflammatory activation in the brain parenchyma (Scheltens et al., 2021). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.