In further experiments, we observed that microglial deficiency of p38α‐MAPK attenuated the cognitive deficits of 12‐month‐old APP‐transgenic mice in Morris water maze test; however, p38α‐MAPK deficiency did not prevent the loss of synaptophysin, Munc18‐1, PSD‐95, and SNAP25 in APP‐transgenic AD mice (Figure S11). The gene discussed is SYP; the disease is Alzheimer disease.